Instructions to Authors
Manuscript Submission
Toxicologic Pathology prefers to receive all manuscript submission electronically via Manuscript Central. Manuscript Central is located at http://mc.manuscriptcentral.com/toxpath. Manuscript Central allows for rapid and easy submission of original and revised manuscripts, as well as reviewing and internal communication between authors, editors and reviewers via a web-based platform.
In order to offset increasing publication costs, the Society has established a standard charge of $250.00 for each accepted manuscript. Payment should be made to Sage Publications by major credit card at the time of manuscript submission through Manuscript Central. Authors are encouraged to submit color figures. There is no charge for color figures.To submit a manuscript, please follow the instructions below:
1. Go to the Toxicologic Pathology’s Manuscript Central homepage http://mc.manuscriptcentral.com/toxpath).
2. Log-in or click the "Create Account" option if you are a first-time user of Manuscript Central.
3. If you are creating a new account:
- After clicking on "Create Account" enter your name and e-mail information and click "Next". Your e-mail information is very important.
- Enter your institution and address information as prompted then click "Next."
- Enter a user ID and password of your choice (we recommend using your e-mail address as your user ID) and then select your area of expertise. Click "Finish" when done.
4. Log-in and select "Author Center."
Submitting Your Manuscript
5. After you have logged in, click the "Submit a Manuscript" link in the menu bar.
6. Enter data and answer questions as prompted
7. Click on the "Next" button on each screen to save your work and advance to the next screen.
8. Your will be prompted to upload your files:
- Click on the "Browse" button and locate the file on your computer.
- Select the description of the file in the drop down next to the Browse button.
- When you have selected all files you wish to upload, click the "Upload" button.
§ a. NOTE: you have a limit of XX MB combined for all files you upload.
9. Review your submission (in both PDF and HTML formats) before sending to the Editors. Click the "Submit" button when you are done reviewing.
You may stop a submission at any phase and save it to submit later. After submission, you will receive a confirmation via e-mail. You can also log-on to Manuscript Central any time to check the status of your manuscript. You will receive an e-mail once a decision has been made on your manuscript.
General Information
Toxicologic Pathology is the official journal of the Society of Toxicologic Pathology and publishes Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, Case Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology. Relevant topics include reports on safety assessment of pharmaceuticals, chemicals, food additives, pesticides, environmentally relevant chemicals, and medical devices; risk characterization of xenobiotics; investigative studies that contribute to refinement of the safety assessment process; mechanistic studies that provide a basis for interpreting and predicting toxicologic outcome; emerging approaches and methods in toxicologic pathology; spontaneous diseases that may influence toxicology studies, and animal and alternative models relevant to toxicologic pathology. Reviews may be contributed or invited.
A cover letter should indicate clearly that the work being submitted for publication constitutes original research and that has not been published and is not under consideration for publication elsewhere.
Manuscript Preparation
Manuscripts are to be submitted to Toxicologic Pathology via Toxicologic Pathology Manuscript Central (http://mc.manuscriptcentral.com/toxpath). If you do not have access to the Internet, please contact the Editorial Office (toxpathjournal@comcast.net)
Submission of an article to Toxicologic Pathology assumes that 1) All authors have made a significant contribution to the article and share the responsibility of the manuscript content and findings. 2) All authors have read and approved the original and any revised version of the article that is submitted. 3) The manuscript has not been previously published and is not under consideration elsewhere. 4) Potential conflict of interest has been disclosed to the Associate Editor (see conflict of interest guidelines).
Original Research Articles submitted will contain:
A Cover letter saved in Microsoft Word format (.doc) or rich text format (.rtf) maybe uploaded to Toxicologic Pathology Manuscript Central. Manuscripts should be double-spaced throughout (including references, footnotes, tables, and figure legends). Original research articles should be organized into sections as follows:
The Title Page should contain the title of the paper, the full names (first name, middle initial, last name) of all authors and the institution(s) where they reside. Changes of address since completion of the work can be included as footnotes.
The Running Title Page should contain a 35-character short title to be used as a running head; in a second line include the last name of the first author followed by "et al." for multiple authored articles. At the bottom of the page, type the full name, address, phone number, and e-mail address of the author who will receive correspondence and proofs.
The Keywords Page facilitates indexing and retrieval services. The system will require you to enter a minimum of 3 and a maximum of 7 keywords.
An Abbreviations Page should define abbreviations used throughout the manuscript and will appear as a footnote on the first page of the final publication.
A Declaration of Conflict of Interest or of Financial Disclosure should be included. Even if there are no conflicts of interest or financial disclosures, this should be stated.
The Abstract should be one paragraph consisting of a 150 to 200 word concise description of the objectives, methods, findings, and significance of the research.
The Introduction should contain brief background information and a clear statement of purpose and significance of the research being reported.
The Materials and Methods should provide a brief description of the methods and experiments and experimental design used. Methods and techniques that are well established should be referenced only. The description of the methods followed should allow reproducibility by other investigators. In reports covering in vivo experimentation, a description of the anesthesia or other procedures to avoid unnecessary pain or suffering should be included. Authors must state their compliance regarding rights of subjects in human experimentation or humane treatment and care of animals in research.
Research Involving Animals:
When studies involve the use of experimental animals, manuscripts should briefly describe the procedures employed for animal care and handling. Experiments that involve the use of animals must be conducted in accordance with institutional and governmental guiding principles in the use of animals.
Research Involving Human Subjects:
Studies involving research on human subjects must be approved by an appropriate Institutional Review Board (IRB) and comply with all relevant federal, state and local regulations. For research conducted outside federal regulations, authors must provide documentation that the research was conducted according to the principles of the Declaration of Helsinki (http://www.wma.net/e/policy/b3.htm). A statement describing IRB approval, consent procedures and that all human participants gave written informed consent must appear at the beginning of the Methods section; the editor may request to see such documentation.
Results should be concerned exclusively with the experimental design described in Methods and be presented as concisely as possible. Tables and figures should illustrate important points.
Discussion should concentrate on the discussion of the findings presented and, in context with other relevant published work, include the major points that add to the significance of the work. Extensive literature reviews or highly speculative discussion are discouraged.
Acknowledgments should be confined to those who contributed to the final presentation not in the role of author. Acknowledgment of technical contributions should be specific for participation, avoiding lengthy recognition that could have been made by other means.
Footnotes should be used sparingly, indicated by Arabic numerals superscripted to the authors, text, or titles. Footnotes should be typed sequentially on a separate page and can include disclaimers, the source of grant support, and address for offprint requests.
Studies involving research on human subjects must be approved by an appropriate Institutional Review Board (IRB) and comply with all relevant federal, state and local regulations. For research conducted outside federal regulations, authors must provide documentation that the research was conducted according to the principles of the Declaration of Helsinki (http://www.wma.net/e/policy/b3.htm). A statement describing IRB approval, consent procedures and that all human participants gave written informed consent must appear at the beginning of the Methods section; the editor may request to see such documentation. should be concerned exclusively with the experimental design described in Methods and be presented as concisely as possible. Tables and figures should illustrate important points.should concentrate on the discussion of the findings presented and, in context with other relevant published work, include the major points that add to the significance of the work. Extensive literature reviews or highly speculative discussion are discouraged.should be confined to those who contributed to the final presentation not in the role of author. Acknowledgment of technical contributions should be specific for participation, avoiding lengthy recognition that could have been made by other means.should be used sparingly, indicated by Arabic numerals superscripted to the authors, text, or titles. Footnotes should be typed sequentially on a separate page and can include disclaimers, the source of grant support, and address for offprint requests.
References. Pertinent literature references should be cited in the text in regular font within parentheses by author and year, e.g., (Smith, 1989; Jones et al., 2001). In the Reference list at the end of the paper, literature should be listed alphabetically by first author. Include the names and initials of all the authors, year of publication between parentheses, full title of paper, reference source abbreviated (use those listed in the Index Medicus), volume, and first and last page. Authors using EndNote may obtain the style file at (www.toxpath.org/toxpath.asp). The following are examples of reference listings:
Pertinent literature references should be cited in the text in regular font within parentheses by author and year, e.g., (Smith, 1989; Jones et al., 2001). In the Reference list at the end of the paper, literature should be listed alphabetically by first author. Include the names and initials of all the authors, year of publication between parentheses, full title of paper, reference source abbreviated (use those listed in the Index Medicus), volume, and first and last page. Authors using EndNote may obtain the style file at (www.toxpath.org/toxpath.asp <http://www.toxpath.org/../toxpath.asp>). The following are examples of reference listings:
Benedetti, S., Pirola, B., Pollo, B., Magrassi, L., Bruzzone, M. G., Rigamonti, D., Galli, R., Selleri, S., Di Meco, F., De Fraja, C., Vescovi, A., Cattaneo, E., and Finocchiaro, G. (2000). Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6, 447-50.
Bos, J., and van Kreijl, C. (1992). Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis. In Mechanisms of Carcinogenesis in Risk Identification (H. Vainio, P. Magee, D. McGregor and A. McMichael, eds.), Vol. 116, pp. 57-65. IARC Scientific Publications, Lyon, France.
National Research Council (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
National Toxicology Program (1996). Toxicology and Carcinogenesis Studies of 1-Amino-2,4-dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 383, NIH Publication No. 96-2838., NIEHS, Research Triangle Park, NC.
Smith, B. R. (2000). Magnetic resonance imaging analysis of embryos. Methods Mol Biol 135, 211-6.
US Environmental Protection Agency (1981). Hazardous waste regulations, 40CFR Part 261., US Government Printing Office. Washington, DC.
The authors are responsible for the accuracy of the references quoted.
Tables should be typed, double-spaced, on separate sheets, numbered consecutively with Roman numerals and referred to in the text. Every table should have a title and each column should have a heading. Table footnotes should be in the form of lowercase superscript characters, listed alphabetically below the last table line. Material included in tables should not be duplicated by figures, or vice versa.
Abbreviations, Chemical Designations. The metric system is the standard for all measurement and variable notations. Abbreviations should be defined between parentheses when first indicated in the text. Italic text should be underlined and Chemical Abstracts or associated indexes should be used for conventional chemical designation. Authors may use, without definition, the following abbreviations:
m = meter
cm = centimeter
cm2 = square centimeter
mm = millimeter
µm = micrometer
nm = nanometer
L = liter
ml = milliliter
µl = microliter
g = gram
kg = kilogram
mg = milligram
µg = microgram
vs = versus
e.g. = for example
i.e. = that is
et al. = and others
Fig. = Figure
min = minutes
sec = seconds
hr = hours
mo = months
yr = years
ic = intracutaneous
mM = millomolar
im = intramascular
ip = intrapertoneal
iv = intravenous
po = oral
sc = subcutaneous
Figures
should be typed, double-spaced, on separate sheets, numbered consecutively with Roman numerals and referred to in the text. Every table should have a title and each column should have a heading. Table footnotes should be in the form of lowercase superscript characters, listed alphabetically below the last table line. Material included in tables should not be duplicated by figures, or vice versa.The metric system is the standard for all
