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Published in Association with International Dose-Response Society
An International Journal

eISSN: 15593258 | ISSN: 15593258 | Current volume: 22 | Current issue: 1 Frequency: Quarterly

Journal Highlights

  • Impact Factor: 2.623
  • Indexed In: Clarivate Analytics: Science Citation Index Expanded (SCIE) and PubMed Central (PMC)
  • Publication is subject to payment of an article processing charge (APC)
  • Submit here

Dose-Response is a peer-reviewed open access journal that publishes high-quality articles reporting the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on mechanistic studies of nonlinear or linear dose-response relationships in low-dose range of the exposome.

This journal is affiliated with the International Dose-Response Society.

This journal is a member of the Committee on Publication Ethics (COPE).

Submission Information

Submit your manuscript today at Please see the Submission Guidelines tab for more information on how to submit your article to the journal.

Open access article processing charge (APC) information

Publication in the journal is subject to payment of an article processing charge (APC). The APC serves to support the journal and ensures that articles are freely accessible online in perpetuity under a Creative Commons license.

The APC is currently 2650 USD. Commentaries are $250 USD, and Letters to the Editor are free of charge.

Members of the International Dose-Response Society can received a 50% discount off the prevailing APC.

The article processing charge (APC) is payable when a manuscript is accepted after peer review, before it is published. The APC is subject to taxes where applicable. Please see further details here.


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Why Publish Open Access with Dose-Response

  • Visibility and Impact: Anyone anywhere in the world can read, use and cite your research
  • Rigorous Standards: Single-blind peer review policy
  • Flexibility: No page limits or page charges, and authors can publish full data sets, figures, tables, etc
  • Copyright: Authors retain copyright under a Creative Commons License

Useful Links

Dose-Response is an open access peer-reviewed online journal publishing will publish high quality, original findings, clinical observation or report, epidemiological analysis, comprehensive or narrative review, letter to the Editor, and editorial specifically for the original work accompanied same issue, on the occurrence of dose-response relationships across a broad range of disciplines. These will include the dose-response investigation in the genomics, epigenetics, biochemistry, molecular biology, physiology and toxicology, pharmacology, medicine, experimental biology, as well as environmental and related sciences, for the responses of these biological variables to environmental chemical, factors, radiation, climate changes (heat, air pollution, geographic variation), life-style change, and even biological stress, and the underlying mechanisms by which nonlinear dose-response occurs. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.

Target Audience
Researchers who explore fundamental hormetic and/or adaptive mechanisms as well as those interested in risk assessments of air pollutions, chemicals, metals, pharmaceuticals, heat (climate) changes, ionizing and non-ionizing radiation, life-style changes, and physiological and pathological (early and late) remodeling and (temporal and permanent) dysfunction.

Article Types
Original research or short reports, clinical observation or case report, comprehensive or narrative reviews on specific topics, commentaries, letters to the editor and also editorial specifically for the original work published in the same issue.

Topics of Interest

  • U-shaped Dose Response
  • J-shaped Dose Response
  • Non-monotonic Dose Response
  • Non-linearity
  • Hormesis/Hormetic Dose Response
  • Biphasic Dose Response
  • Pre/Post Conditioning
    Adaptive Response
  • Drug resistance
  • Mechanistic study on the difference for low and high dose effect
  • Essential and non-essential metal toxic differences
  • Interruption of the Dose-Response with two-hits

View a selection of the latest papers published in Dose-Response

Manuscript Submission

Editor-in- Chief
Lu Cai University of Louisville, USA
Executive Editor
Ying Lou, PhD SAGE Publishing, China
Associate Editor
Fenghao Geng Sichuan University, China
Qiang Liu Chinese Academy of Medical Science & Peking Union Medical College, China
Rongzhu Lu Jiangsu University, China
Yi Tan University of Louisville, USA
Bing Wang National Institutes for Quantum Science and Technology, Japan
James S. Welsh Loyola University Chicago's Stritch School of Medicine, USA
Editor Emeritus
Edward J. Calabrese University of Massachusetts, USA
Barbara G. Callahan University of Massachusetts, USA
Editorial Board
Jean Lud Cadet NIH/NIDA IRP, USA
Chris Cutler Nova Scotia Agricultural College, Canada
Li Feng Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging, China
George Gray George Washington University, USA
Jaap Hanekamp Roosevelt Academy, Netherlands
Seyed Alireza Javadinia, MD, Assistant Professor Sabzevar University of Medical Sciences, Iran
Jui-An Lin Chung Shan Medical University Hospital, Taiwan
Yan Liu Binzhou Medical University, China
Yan Liu Queensland University, Australia
Mark Mattson NIA, India
Ken Maynard Takeda Pharmaceuticals International, Inc., Switzerland
Jay Mitchell Harvard, USA
Zsolt Radak Semmelweis University, Hungary
Suresh Rattan Univerity of Aarhus, Denmark
Michael Ristow University of Jena, Germany
Bobby Scott Lovelace Respiratory Research Institute, USA
David Sinclair Harvard Medical School, USA
Huijuan Song Chinese Academy of Medical Sciences & Peking Union Medical College, China
Wenling Tu The Second Affiliated Hospital of Chengdu Medical College, China
Brant Ulsh M.H. Chew and Associates, USA
Bo Wang HaiNan Medical University, China
Zhen Wang Huazhong University of Science and Technology, China
Reinhard Wetzker University of Jena, Germany
Chang Xu Chinese Academy of Medical Sciences & Peking Union Medical College, China
Xuelin Zhou Capital Medical University, China
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  • ProQuest
  • ProQuest: CSA Toxicology Abstracts
  • PubMed Central (PMC)
  • Manuscript submission guidelines can be accessed on Sage Journals.